Article

The <i>SAMM50</i> rs3761472 causes mitochondrial dysfunction and metabolic dysfunction-associated steatotic liver disease

2025-06-07

Abstract excerpt

Genome-wide association studies (GWAS) have identified the SAMM50 rs3761472 single nucleotide polymorphism (SNP) as a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), although its in vivo functions remain unclear. SAMM50 encodes a mitochondrial outer membrane protein critical for maintaining mitochondrial structure. To investigate the biological effects of rs3761472, we generated...

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Literature Corpus work: 729e295d-e65e-54f3-b96e-32af64315148
DOI: 10.1101/2025.06.04.657815

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