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Article

SAMM50 rs3761472 causes mitochondrial dysfunction and progression of metabolic dysfunction-associated steatotic liver disease.

Molecular metabolism - 1 Sept 2026

Kim Suyeon, Kim Young Jin, Kim Nahyun, Kim Uijin, Park Yi Seul, Yun Jun Ho, Heo Jiwon, Lee Hyunwoo, Choi Jiwon, Park Sinwoo, Jeong Inhae, Kim Bong-Jo, Shin Ha Youn

Abstract excerpt

OBJECTIVES: SAMM50 rs3761472 is associated with metabolic dysfunction-associated steatotic liver disease (MASLD), but its functional consequences in vivo remain unclear. We investigated whether this variant disrupts mitochondrial function and promotes MASLD progression. METHODS: Associations of rs3761472 with MASLD and liver-related traits were evaluated using Korea Biobank Array data. We generated Samm50...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42468840
DOI: 10.1016/j.molmet.2026.102423
PMCID: PMC13446200

Genes

SAMM50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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