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Exploring Cerebellar–Hippocampal Dynamics in Temporal Lobe Epilepsy: A Multivariable Synthetic Modeling Study of Purkinje Cell Degeneration and Stimulation Timing

2025-08-15

Abstract excerpt

<h4>Objective</h4> To investigate whether Purkinje cell degeneration precedes or follows seizure onset in temporal lobe epilepsy (TLE), delineate shared cerebello-hippocampal pathways, and assess the influence of stimulation timing on modeled seizure outcomes. <h4>Methods</h4> We developed a comprehensive 50-variable evidence model integrating structural, molecular, and circuit-level variables sourced from exist...

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Literature Corpus work: e83ed9ba-f340-55dc-b94c-f269cba4c99d
DOI: 10.1101/2025.08.13.670211

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Exploring Cerebellar–Hippocampal Dynamics in Temporal Lobe Epilepsy: A Multivariable Synthetic Modeling Study of Purkinje Cell Degeneration and Stimulation TimingDOI 10.1101/2025.08.13.670211Read

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