Article

Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1

2019-02-02

Abstract excerpt

<h4>ABSTRACT</h4> The nucleoside analog 5-aza-2’-deoxycytidine (5-aza-dC) is used to treat some hematopoietic malignancies. The mechanism of cell killing depends upon DNMT1, but is otherwise not clearly defined. Here we show that PARP1 forms covalent DNA adducts in human lymphoblast or fibroblasts treated with 5-aza-dC. Some adducts recovered from 5-aza-dC-treated cells have undergone cleavage by apoptotic caspas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68032819-d55c-5209-8e47-0f0181a9840c
DOI: 10.1101/538645

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1DOI 10.1101/538645Read

Comprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profilingSemantic proximity Read

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesionsSemantic proximity Read

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.Semantic proximity Read

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response ProteinsSemantic proximity Read

PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral DynamicsSemantic proximity Read

New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancersSemantic proximity Read

A Phase I Study of ASTX727 plus Talazoparib in Patients with Triple Negative or Hormone Resistant/HER2-negative Metastatic Breast CancerSemantic proximity Read

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibitionSemantic proximity Read

5-Aza-4’-thio-2’-deoxycytidine induces C>G transversions in a specific trinucleotide context and leads to acute lymphoid leukemiaSemantic proximity Read

GSK-3484862 targets DNMT1 for degradation in cellsSemantic proximity Read

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibitionSemantic proximity Read

Hematologic complications in patients exposed to PARP inhibitorsSemantic proximity Read