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Article

Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells

1 Nov 2016

Abstract excerpt

PURPOSE: Fuchs' endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium that leads to vision loss, is a leading cause of corneal transplantation. The cause of this disease is still unknown, but the implication of oxidative stress is strongly suggested. In this study, we analyzed the impact of FECD on mitochondrial DNA (mtDNA) integrity and telomere length, both of which are...

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Share to Corneal surgery and disorders
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Share to Telomeres, Telomerase, and Senescence

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PMID: 27802523
DOI: 10.1167/iovs.16-20551

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