Back to search

Article

Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes

2024-10-29

Abstract excerpt

<h4>Background</h4> Cardiovascular mortality in chronic kidney disease (CKD) remains disproportionately high, yet the mechanisms linking renal dysfunction to cardiac vulnerability are incompletely understood. Uraemic cardiomyopathy is increasingly recognised as a systemic metabolic disease, but the contribution of multi-organ bioenergetic failure in cardiac dysfunction is poorly defined. <h4>Hypothesis</h4> CKD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
72176836-33d5-59d6-8580-91f34eed75e1
DOI
10.1101/2024.10.24.620055
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomesDOI 10.1101/2024.10.24.620055
Bioenergetics: the evolutionary basis of progressive kidney diseaseSemantic proximity
Mitochondrial Bioenergetic and Proteomic Phenotyping Reveals Organ-Specific Consequences of Chronic Kidney Disease in Mice.Semantic proximity
The response of the skeletal muscle transcriptome to exercise in chronic kidney diseaseSemantic proximity
Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney diseaseSemantic proximity
Multiomics identifies unique modulators of calf muscle pathophysiology in peripheral artery disease and chronic kidney diseaseSemantic proximity
Anabolic and catabolic responses to different modes of exercise in patients with chronic kidney diseaseSemantic proximity
Molecular imaging along the heart-kidney axisSemantic proximity
Adenine-induced kidney disease alters the cortical bone metabolome of C57BL/6J mice in a manner that depends on sexSemantic proximity
A High-fat, High-salt Diet Model of MDAKD Impairs Bioenergetic Efficiency for ATP SynthesisSemantic proximity
Diastolic Dysfunction and Impaired Cardiac Output Reserve in Dysmetabolic Nonhuman Primate With ProteinuriaSemantic proximity
A murine model of cardiovascular-kidney-metabolic syndrome demonstrates compromised limb function in the ischemic hind limbSemantic proximity
Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injurySemantic proximity
Select a neighboring publication to make it the new centre.