TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein

Abstract excerpt

The tripartite motif (TRIM) protein family is the largest subfamily of E3 ubiquitin ligases, playing a crucial role in the antiviral process. In this study, we found that TRIM72, a member of the TRIM protein family, was increased in neuronal cells and mouse brains following rabies lyssavirus (RABV) infection. Over-expression of TRIM72 significantly reduced the viral titer of RABV in neuronal cells and mitigated th...

Topics

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• Autophagy in Disease and Therapy
• Cytomegalovirus and herpesvirus research
• Herpesvirus Infections and Treatments
• interferon and immune responses
• Mosquito-borne diseases and control
• Rabies epidemiology and control
• Toxoplasma gondii Research Studies
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

720de971-5996-5044-8aea-79e403c8e0be

DOI

10.1101/2023.09.29.560081