Article

Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains

2023-10-20

Abstract excerpt

<title>Abstract</title> <p>The vaccine elicitation of HIV-neutralizing antibodies with tier-2-neutralization breadth has been a challenge. Here, we report the isolation and characteristics of a CD4-binding site specific monoclonal antibody, HmAb64, from a human volunteer immunized with a polyvalent gp120 DNA prime-protein boost vaccine. HmAb64 derived from heavy chain variable germline gene IGHV1-18, light chain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 518935be-e0e6-54f3-b46d-f099f9e9ee1b
DOI: 10.21203/rs.3.rs-3360161/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV StrainsDOI 10.21203/rs.3.rs-3360161/v1Read

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Semantic proximity Read

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV NeutralizationSemantic proximity Read

A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus MacaquesSemantic proximity Read

Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humansSemantic proximity Read

Structural identification of neutralizing antibodies induced by nucleic acid encoded native-like trimerSemantic proximity Read

Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccinesSemantic proximity Read

A naturally arising broad and potent CD4-binding site antibody with low somatic mutationSemantic proximity Read

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaquesSemantic proximity Read

Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-class antibodiesSemantic proximity Read

A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human VolunteersSemantic proximity Read

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.Semantic proximity Read