Article

Uptake of aminoglycosides through outer membrane porins in <i>Escherichia coli</i>

2022-09-05

Abstract excerpt

Aminoglycosides are important clinical antibiotics but their molecular uptake mechanism is still not completely understood. Here we quantify and compare the passive transport of three aminoglycosides (kanamycin, gentamicin, and amikacin) across general or sugar specific porins of Escherichia coli (OmpF, OmpC, LamB and ChiP). Our analysis revealed that permeation of aminoglycosides (Kanamycin/Gentamycin/Amikacin)...

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Literature Corpus work: 7155906d-e728-597a-aafa-62581691d334
DOI: 10.1101/2022.09.05.506620

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