Article
The bacterial outer membrane as a drug barrier.
Trends in microbiology - 1 Jan 1997
Hancock R E
Abstract excerpt
The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy wi...
Topics
- Anti-Bacterial Agents
- Cations
- Cell Membrane
- Cell Membrane Permeability
- Drug Resistance, Microbial
- Gram-Negative Bacteria
- Molecular Structure
- Mutation
- beta-Lactamases
- beta-Lactams