Article

The Effects of Different Histone Deacetylase Inhibitors on Hypoxia-induced Intestinal Epithelial Barrier Dysfunction and a Preliminary Exploration of the Mechanisms

2022-11-07

Abstract excerpt

<h4>Aim: </h4> We aimed to compare the effects and underlying mechanisms of 6 different representative HDAC inhibitors (MS-275, MC-1568, Tubastatin-A (Tub-A), EX-527, Vorinostat Suberoylanilide hydroxamic acid (SAHA) and Valproic Acid (VPA)) in hypoxia-induced intestinal epithelial barrier dysfunction based on in vitro Caco-2 cell experiments and network pharmacology combined with bioinformatics analysis. <h4>Met...

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Literature Corpus work: 711600a9-499d-50d1-adbd-bf7e05a08056
DOI: 10.21203/rs.3.rs-2176731/v1

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