Article

Latent factor in Brain RNA-seq studies reflects cell type and clinical heterogeneity

2022-11-16

Abstract excerpt

With the growing availability of Alzheimer’s disease (AD) transcriptomic data, several studies have nominated new therapeutic targets. However, a major challenge is accounting for latent (hidden) factors which affect the discovery of therapeutic targets. Using unsupervised machine learning, we identified a latent factor in brain tissue, and we validated the factor in AD and normal samples, across multiple studies,...

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Literature Corpus work: 70db3e78-191c-5aab-a75f-f1ea2fcfb6d1
DOI: 10.1101/2022.11.13.516360

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