Article

Multi-modal Latent Factor Exploration of Atrophy, Cognitive and Tau Heterogeneity in Alzheimer’s Disease

2018-11-08

Abstract excerpt

Individuals with Alzheimer’s disease (AD) dementia exhibit significant heterogeneity across clinical symptoms, atrophy patterns, and spatial distribution of Tau deposition. Most previous studies of AD heterogeneity have focused on atypical clinical subtypes, defined subtypes with a single modality, or restricted their analyses to a priori brain regions and cognitive tests. Here, we considered a data-driven hierarc...

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Literature Corpus work: cd242fb4-ad40-59bd-8864-414e4832b81c
DOI: 10.1101/462143

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