Article

A Personalized Metabolic Modelling Approach through Integrated Analysis of RNA-Seq-Based Genomic Variants and Gene Expression Levels in Alzheimer’s Disease

2024-04-28

Abstract excerpt

<h4>Motivation</h4> Alzheimer’s disease (AD) is known to cause alterations in brain metabolism. Furthermore, genomic variants in enzyme-coding genes may exacerbate AD-linked metabolic changes. Generating condition-specific metabolic models by mapping gene expression data to genome-scale metabolic models is a routine approach to elucidate disease mechanisms from a metabolic perspective. RNAseq data provides both g...

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Literature Corpus work: 50d20283-e1dd-5c03-a107-04ec61ba4510
DOI: 10.1101/2024.04.24.590807

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