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Article

Integrative analysis of multi-omics and imaging data with incorporation of biological information via structural Bayesian factor analysis.

Briefings in bioinformatics - 19 Mar 2023

Bao Jingxuan, Chang Changgee, Zhang Qiyiwen, Saykin Andrew J, Shen Li, Long Qi

Abstract excerpt

MOTIVATION: With the rapid development of modern technologies, massive data are available for the systematic study of Alzheimer's disease (AD). Though many existing AD studies mainly focus on single-modality omics data, multi-omics datasets can provide a more comprehensive understanding of AD. To bridge this gap, we proposed a novel structural Bayesian factor analysis framework (SBFA) to extract the information...

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PMID: 36882008
DOI: 10.1093/bib/bbad073
PMCID: PMC10387302

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