Article

Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease

2024-12-17

Abstract excerpt

<h4>Summary</h4> Parkinson’s disease (PD) is associated with gut microbiome shifts, but the functional consequences remain unclear. Here, we use an integrated multi-omics approach to compare the gut microbiomes of individuals with PD and prodromal PD as well as healthy individuals. After analyzing each omics, meta-metabolomic was selected to inform the analysis as it represents the most discriminatory and robust...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 347cb9d2-d28e-5f2f-860a-9d124209fb24
DOI: 10.1101/2024.12.13.628341

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s diseaseDOI 10.1101/2024.12.13.628341Read

Integrated multi-cohort analysis of the Parkinson’s disease gut metagenomeSemantic proximity Read

Parkinson’s disease-associated alterations of the gut microbiome can invoke disease-relevant metabolic changesSemantic proximity Read

Integrated Multi‐Cohort Analysis of the Parkinson's Disease Gut MetagenomeSemantic proximity Read

Metagenomic Analysis Reveals Large‐Scale Disruptions of the Gut Microbiome in Parkinson's DiseaseSemantic proximity Read

Metagenomics of the Gut Microbiome in Parkinson's Disease: Prodromal ChangesSemantic proximity Read

Microbial biomarker discovery in Parkinson’s disease through a network-based approachSemantic proximity Read

Gut microbiome-based secondary metabolite biosynthetic gene clusters detection in Parkinson’s diseaseSemantic proximity Read

Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson’s diseaseSemantic proximity Read

Microbiome-to-Nigrostriatal Vulnerability Mapping Prioritizes SCFA-Linked Gut-Brain Axes in Parkinson’s DiseaseSemantic proximity Read

Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanismsSemantic proximity Read

Microbiome signature of Parkinson disease in healthy and genetically at-risk individualsSemantic proximity Read

Microbiome-to-Nigrostriatal Vulnerability Mapping Prioritizes SCFA-Linked Gut-Brain Axes in Parkinson’s DiseaseSemantic proximity Read