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Article

Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolism.

Gut microbes - 31 Dec 2026

Kim Doyeon, Li Minshu, Nguyen Thi Ha, Choi Yu-Jeong, Jang Sojeong, Kim Minhyeong, Kim Young-Kwang, Shin Min-Kyoo, de Guzman Arvie Camille V, Park Sunghyouk

Abstract excerpt

The gut microbiome modulates host neuropathology, but the mechanisms linking specific microbial genes and metabolites to host phenotypes remain poorly defined. Here, we identify microbiome-derived vitamin B6 (VB6) and its biosynthesis gene as key regulators of host dopaminergic homeostasis. Metagenomic analysis of fecal samples from Parkinson's disease (PD) patients revealed enrichment of biosynthetic pathways...

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alpha-Synuclein
Bacteria
Dopamine
Feces
Gastrointestinal Microbiome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Pyridoxal Phosphate

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Identifiers

PMID: 42400260
DOI: 10.1080/19490976.2026.2695485
PMCID: PMC13348962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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