Article

Polygenic Risk Scores in the Early Detection of Cancer and Autoimmune Disease in Patients with Non-Specific Symptoms: Insights from the SCAN Cohort

2026-07-03

Abstract excerpt

<title>Abstract</title> <p>Background Early detection of cancer and autoimmune disease is challenging in patients with non-specific symptoms. Polygenic risk scores (PRS) capture inherited susceptibility to disease and may help refine risk stratification, but their clinical utility in symptomatic, referred populations remains uncertain. Methods We analysed germline DNA from 2,000 patients referred to the Oxfords...

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Literature Corpus work: 70b08fa1-a195-5ecb-9aba-ab35c4e22b8e
DOI: 10.21203/rs.3.rs-9829206/v1

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