Article

Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing

2020-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Base editing is a genome-editing approach that employs the CRISPR/Cas system to precisely install point mutations within the genome. A cytidine or adenosine deaminase enzyme is fused to a deactivated Cas and converts C to T or A to G, respectively. The diversified repertoire of base editors, varied in their Cas and deaminase proteins, provides a wide range of functionality. However, existing bas...

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Literature Corpus work: 709c1d8e-55d1-58b6-aae1-50f26700266b
DOI: 10.1101/2020.01.06.890244

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