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Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy - 1 Mar 2018

Igawa Gene, Yamagishi Yuka, Lee Ken-Ichi, Dorin Misato, Shimuta Ken, Suematsu Hiroyuki, Nakayama Shu-Ichi, Mikamo Hiroshige, Unemo Magnus, Ohnishi Makoto

Abstract excerpt

Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae, but their evolution is mostly unknown. The penA gene from Neisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 μg/ml) caused ceftriaxone resistance (MIC, 1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3'-terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal...

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Identifiers

PMID: 29311079
DOI: 10.1128/AAC.02069-17
PMCID: PMC5826163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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