Article

Combination of artesunate and ruxolitinib inhibits T-lymphoblastic leukemia/lymphoma proliferation via the Janus kinase/signal transducer and activator of transcription pathway

2025-09-25

Abstract excerpt

<title>Abstract</title> <p>BACKGROUND T-lymphoblastic leukemia/lymphoma is a highly aggressive malignancy, and its prognosis after relapse is poor, with a 5-year overall survival rate of 35%. Mutations in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway are the second most common mutation type in T-lymphoblastic leukemia/lymphoma, and hyperactivation of this pathway can promote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7050241a-f7a8-5d71-ac2c-bc4d68a68342
DOI: 10.21203/rs.3.rs-7241143/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Combination of artesunate and ruxolitinib inhibits T-lymphoblastic leukemia/lymphoma proliferation via the Janus kinase/signal transducer and activator of transcription pathwayDOI 10.21203/rs.3.rs-7241143/v1Read

Synergistic Antileukemic Effects of Hydroxyurea and SRJ23 in T-cell Acute Lymphoblastic LeukemiaSemantic proximity Read

Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation.Semantic proximity Read

In Vitro Evaluation of the Potential Synergistic Interactions Between Apigenin and Bortezomib in U266 Multiple Myeloma CellsSemantic proximity Read

Combination of Artesunate and WNT974 Induces KRAS Protein Degradation by Upregulating E3 Ligase ANACP2 and β-TrCP in the Ubiquitin–Proteasome PathwaySemantic proximity Read

Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling.Semantic proximity Read

The antipsychotic drug pimozide is a novel chemotherapeutic agent for adult T cell leukemiaSemantic proximity Read

Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV‐1‐infected T‐cells <i>in vitro</i>Semantic proximity Read

Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivoSemantic proximity Read

Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients.Semantic proximity Read

Effect of Rapamycin Treatment in Human Seminoma TCam-2 Cells through Inhibition of G1-S TransitionSemantic proximity Read

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphomaSemantic proximity Read