Article
Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling.
Pharmacological reports : PR - 1 Apr 2015
Yang Nanmu, Han Feng, Cui Hong, Huang Jinxi, Wang Tao, Zhou Yi, Zhou Jinxue
Abstract excerpt
BACKGROUND: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) signaling contributes to apoptosis resistance in cholangiocarcinoma. The aim of this study is to check whether matrine, an alkaloid isolated from traditional Chinese herb Sophora flavescens ait, can exert cytotoxic effects against cholangiocarcinoma cells via inactivation of STAT3 signaling. METHODS: Mz-ChA-1 and...
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