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Article

Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial–mesenchymal transition

1 Sept 2014

Abstract excerpt

OBJECTIVES: Osteosarcoma (OS) is one of the most common primary malignant bone tumours of childhood and adolescence, and is characterized by high propensity for metastasis (specially to the lung), which is the main cause of death. However, molecular mechanisms underlying metastasis of OS are still poorly understood. MATERIALS AND METHODS: Metadherin (MTDH) was identified to be significantly upregulated in OS...

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PMID: 25174891
DOI: 10.1111/cpr.12129

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