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Article

ANXA3 activates HIF-1α/VEGF Signaling Via the PI3K/AKT/mTOR Pathway to Promote Osteosarcoma Stem Cell-Like Phenotype.

Stem cell reviews and reports - 1 Aug 2026

Wang Shengtao, Sun Yan, Peng Wei, Sui Yuhan, Xu Shujuan, Bai Yufan, Li Zhaoxu, Zhao Wenzhi

Abstract excerpt

BACKGROUND: Aberrant activation of HIF‑1α contributes to the maintenance of CSC phenotypes in various malignancies. Our previous work revealed that ANXA3 is up‑regulated in OS cells. Here, we further investigated how ANXA3 regulates CSC‑like properties of OS cells through the HIF‑1α/VEGF signaling pathway. METHODS: Lentiviral vectors were used to modulate ANXA3 expression in OS cell lines. The expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42313237
DOI: 10.1007/s12015-026-11158-w
PMCID: PMC13354625

Genes

ANXA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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