Article

Utilisation of semiconductor sequencing for detection of actionable fusions in solid tumours

2021-01-27

Abstract excerpt

Oncogenic fusions represent compelling druggable targets in solid tumours highlighted by the recent site agnostic FDA approval of larotrectinib for NTRK rearrangements. However screening for fusions in routinely processed tissue samples is constrained due to degradation of nucleic acid as a result of formalin fixation., To investigate the clinical utility of semiconductor sequencing optimised for detection of acti...

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Literature Corpus work: 70410186-b781-5d90-a9d7-ea2580dbfa8a
DOI: 10.1101/2021.01.27.428383

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