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Article

Impaired nuclear transport induced by juvenile ALS causing P525L mutation in NLS domain of FUS: A molecular mechanistic study.

Biochimica et biophysica acta. Proteins and proteomics - 1 Apr 2022

Basu Sushmita, Rajendra K C, Alagar Suresh, Bahadur Ranjit Prasad

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD) are progressive neurological disorders affecting motor neurons. Cellular aggregates of fused in sarcoma (FUS) protein are found in cytoplasm of ALS and FTLD patients. Nuclear localisation signal (NLS) domain of FUS binds to Karyopherin β2 (Kapβ2), which drives nuclear transport of FUS from cytoplasm. Several pathogenic mutations are...

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Identifiers

PMID: 35134572
DOI: 10.1016/j.bbapap.2022.140766

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