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<i>Staphylococcus aureus</i> uses the bacilliredoxin (BrxAB)/ bacillithiol disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections

2019-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Staphylococcus aureus is a major human pathogen and has to cope with reactive oxygen and chlorine species (ROS, RCS) during infections. The low molecular weight thiol bacillithiol (BSH) is an important defense mechanism of S. aureus for detoxification of ROS and HOCl stress to maintain the reduced state of the cytoplasm. Under HOCl stress, BSH forms mixed disulfides with proteins, termed as S...

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Literature Corpus work
6fd13b17-87bd-5e40-a31e-551131014a70
DOI
10.1101/624676
Open publication

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