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MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus

13 Feb 2023

Abstract excerpt

Abstract The major pathogen Staphylococcus aureus has to cope with host‐derived oxidative stress to cause infections in humans. Here, we report that S. aureus tolerates high concentrations of hypothiocyanous acid (HOSCN), a key antimicrobial oxidant produced in the respiratory tract. We discovered that the flavoprotein disulfide reductase (FDR) MerA protects S. aureus from this oxidant by functioning as a HOSCN...

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PMID: 36779383
DOI: 10.1111/mmi.15035

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