Article

Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons

2025-06-29

Abstract excerpt

TAR DNA-binding protein 43 kDa (TDP-43) is an essential splicing repressor whose loss of function underlies the pathophysiology of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). Nuclear clearance of TDP-43 disrupts its function and leads to the inclusion of aberrant cryptic exons. These cryptic exons frequently introduce premature termination codons resulting in the degradation of affected tr...

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Literature Corpus work: 6fc8c698-dc01-5094-b5e5-147d1225dcc1
DOI: 10.1101/2025.06.28.661837

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