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Article

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

26 May 2017

Abstract excerpt

BACKGROUND: Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion causes the aberrant inclusion of cryptic exons into a range of transcripts, but their extent, relevance to disease pathogenesis...

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PMID: 28549443
DOI: 10.1186/s12920-017-0274-1

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