Article

Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential

2025-11-23

Abstract excerpt

Cryptic splicing caused by TDP-43 proteinopathy is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, which cryptic splicing events (CEs) are the most sensitive to TDP-43 depletion, where CEs localise within cells, and how specific CEs are in human tissues is poorly defined. Analyses of in vitro TDP-43 knockdowns and postmortem RNA-seq data...

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Literature Corpus work: 02dda3b4-4c93-5634-abdc-3115dfa0143e
DOI: 10.1101/2025.11.23.689722

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