Article

Mis-spliced transcripts generate <i>de novo</i> proteins in TDP-43-related ALS/FTD

2023-01-23

Abstract excerpt

Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons can promote degradation of affected transcripts, deleteriously altering cellular function through loss-of-function mechanisms. However, the possibility of de novo protein synthesis from cryptic exon transcripts has not...

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Literature Corpus work: 2761918e-b89c-5ce9-a7f4-e03fb2522f54
DOI: 10.1101/2023.01.23.525149

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