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Article

Tdp-43 cryptic exons are highly variable between cell types

2 Feb 2017

Abstract excerpt

BACKGROUND: TDP-43 proteinopathy is a prominent pathological feature that occurs in a number of human diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and inclusion body myositis (IBM). Our recent finding that TDP-43 represses nonconserved cryptic exons led us to ask whether cell type-specific cryptic exons could exist to impact unique molecular pathways in brain or muscle....

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PMID: 28153034
DOI: 10.1186/s13024-016-0144-x

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