Article

Early lethality of embryos derived from transgenic <i>Xenopus</i> females is associated with reduced ovarian <i>grem1</i> expression

2018-02-20

Abstract excerpt

The grem1 gene codes a protein that inhibits the action of multiple members of a growth factor family known as bone morphogenetic proteins (BMPs). Certain members of this BMP family can regulate both fecundity and fertility in mammals via their action on oocyte (egg) development, and grem1 has been identified as a marker of oocyte quality in humans. The model amphibian Xenopus laevis is far more fecund than mam...

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Literature Corpus work: 6fbf765f-6c64-53cf-9878-7518c785f31a
DOI: 10.1101/268235

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