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Reprogramming of Ovine Somatic Cells with <i>Xenopus laevis</i> Oocyte Extract Prior to SCNT Improves Live Birth Rate

1 Oct 2010

Abstract excerpt

The birth of live animals following somatic cell nuclear transfer (SCNT) has demonstrated that oocytes can reprogram the genome of differentiated cells. However, in all species the frequency of development of healthy offspring is low; for example, in sheep, approximately only 5% of blastocysts transferred develop to term, and less than 3% develop to adulthood. Such low efficiencies, coupled with the occurrence of...

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PMID: 20936909
DOI: 10.1089/cell.2010.0015

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