Article

RNase 2/EDN cleaves tRNA anticodon loops to generate immunoactive RNAs

2019-10-24

Abstract excerpt

The RNase A superfamily, one of the most extensively studied enzyme families, remains incompletely defined with respect to its endogenous RNA substrates, recognition mechanisms, and physiological functions. Here, we identify eosinophil-derived neurotoxin (EDN/RNase 2) as a principal endoribonuclease mediating tRNA cleavage in the asthmatic lung. Inhalation of house dust mite (HDM) in mice induces robust accumulati...

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Literature Corpus work: 6fb1bf96-916a-5349-ab94-c26b4b4eb034
DOI: 10.1101/815803

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