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Article

A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.

Nature genetics - 1 Oct 2010

Hysi Pirro G, Young Terri L, Mackey David A, Andrew Toby, Fernández-Medarde Alberto, Solouki Abbas M, Hewitt Alex W, Macgregor Stuart, Vingerling Johannes R, Li Yi-Ju, Ikram M Kamran, Fai Lee Yiu, Sham Pak C, Manyes Lara, Porteros Angel, Lopes Margarida C, Carbonaro Francis, Fahy Samantha J, Martin Nicholas G, van Duijn Cornelia M, Spector Timothy D, Rahi Jugnoo S, Santos Eugenio, Klaver Caroline C W, Hammond Christopher J

Abstract excerpt

Myopia and hyperopia are at opposite ends of the continuum of refraction, the measure of the eye's ability to focus light, which is an important cause of visual impairment (when aberrant) and is a highly heritable trait. We conducted a genome-wide association study for refractive error in 4,270 i...

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Identifiers

PMID: 20835236
DOI: 10.1038/ng.664
PMCID: PMC4115148

Genes

RASGRF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20835236-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.PMID 20835236Read ↗

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Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future.Semantic proximity Read ↗

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Association study of 15q14 and 15q25 with high myopia in the Han Chinese population.Semantic proximity Read ↗

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Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.Semantic proximity Read ↗

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