Back to search

Article

Naturally acquired IgG responses to <i>Plasmodium falciparum</i> do not target the conserved termini of the malaria vaccine candidate merozoite surface protein 2

2024-09-26

Abstract excerpt

Malaria remains a significant burden, and a fully protective vaccine against Plasmodium falciparum is critical for reducing morbidity and mortality. Antibody responses against the blood-stage antigen merozoite surface protein 2 (MSP2) are associated with protection from P. falciparum malaria, but its extensive polymorphism is a barrier to its development as a vaccine candidate. New tools, such as long-read seque...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6f3524cd-bcb5-5749-873b-488da7811f36
DOI
10.1101/2024.09.24.614082
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Naturally acquired IgG responses to <i>Plasmodium falciparum</i> do not target the conserved termini of the malaria vaccine candidate merozoite surface protein 2DOI 10.1101/2024.09.24.614082
Dose-sparing self-amplifying RNA vaccine induces high functional antibodies to blood-stage <i>Plasmodium falciparum</i> malariaSemantic proximity
Variant-specific antibodies to merozoite surface protein 2 and clinical expression of Plasmodium falciparum malaria in rural Amazonians.Semantic proximity
Systematic Serological Diversity of a Putative Malaria Vaccine Candidate and Broad ProtectionSemantic proximity
Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to <i>Plasmodium falciparum</i> Malaria for Vaccine and Biomarker DevelopmentSemantic proximity
Genetic Sequence Variation in the <i>Plasmodium falciparum </i>Histidine-rich Protein 2 Gene from Field Isolates in Tanzania: Impact on Malaria Rapid DiagnosisSemantic proximity
Diversity and selection analyses identify transmission-blocking antigens as the optimal vaccine candidates in<i>Plasmodium falciparum</i>Semantic proximity
Plasmodium falciparum: sequence diversity and antibody recognition of the Merozoite surface protein-2 (MSP-2) in Brazilian Amazonia.Semantic proximity
An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodiesSemantic proximity
Navigating parasite antigen genetic diversity in the design of Plasmodium vivax serological exposure markers for malariaSemantic proximity
Molecular and functional properties of human <i>Plasmodium falciparum</i> CSP C-terminus antibodiesSemantic proximity
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccineSemantic proximity
Unlocking the Global Antigenic Diversity and Balancing Selection of<i>Plasmodium falciparum</i>Semantic proximity
Select a neighboring publication to make it the new centre.