Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

1 Jan 2022

Abstract excerpt

Background & Aims Efforts to characterize the signaling mechanisms that underlie gastroenteropancreatic neoplasms (GEP-NENs) are precluded by a lack of comprehensive models that recapitulate pathogenesis. Investigation into a potential cell-of-origin for gastrin-secreting NENs revealed a non-cell autonomous role for loss of menin in neuroendocrine cell specification, resulting in an induction of gastrin in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital gastrointestinal and neural anomalies
Share to Hedgehog Signaling Pathway Studies
Share to Neuroendocrine Tumor Research Advances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35835391
DOI: 10.1016/j.jcmgh.2022.06.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine ReprogrammingPMID 35835391Read ↗

GFAP-directed Inactivation of <i>Men1</i> Exploits Glial Cell Plasticity in Favor of Neuroendocrine ReprogrammingSemantic proximity Read ↗

Hedgehog signaling drives glial cell plasticity and oncogenic reprogramming in gastroenteropancreatic neuroendocrine neoplasmsSemantic proximity Read ↗

Menin-MLL Inhibitor MI-503 Blocks Menin Nuclear Export and Suppresses HypergastrinemiaSemantic proximity Read ↗

Tracing Early Molecular Drivers of Gastrinoma in MEN1: A Systematic Review for Precision Surveillance and Improved Patient OutcomesSemantic proximity Read ↗

Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.Semantic proximity Read ↗

Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous systemSemantic proximity Read ↗

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.Semantic proximity Read ↗

BRAFV600E Expression in Mouse Neuroglial Progenitors Increase Neuronal Excitability, Cause Appearance of Balloon-like cells, Neuronal Mislocalization, and Inflammatory Immune responseSemantic proximity Read ↗

Epigenetic Regulation of the lncRNA MEG3 and Its Target c-MET in Pancreatic Neuroendocrine TumorsSemantic proximity Read ↗

<i>Mash1</i>Is Required for Generic and Subtype Differentiation of Hypothalamic Neuroendocrine CellsSemantic proximity Read ↗

Enteric glia regulate Paneth cell secretion and intestinal microbial ecologySemantic proximity Read ↗

Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.