Article

HIV Vpr induces demethylation of the SNCA antisense promoter leading to neurocognitive impairment

2025-11-01

Abstract excerpt

<title>Abstract</title> <p> Alpha-synuclein (α-Syn) aggregation is a hallmark of neurodegenerative diseases. In individuals with HIV-1, cognitive impairments are associated with α-Syn accumulation and aggregation. The direct mechanistic link between α-Syn dysregulation and HIV-associated neurocognitive disorders (HAND) remains unclear. Emerging evidence suggests epigenetic changes, particularly DNA demethylation...

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Literature Corpus work: 6ee824fa-416d-5a9e-a5d4-145699c4d6fe
DOI: 10.21203/rs.3.rs-6405901/v1

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