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α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia

18 Jan 2025

Abstract excerpt

HIV-associated neurocognitive disorders (HAND) and viral reservoirs in the brain remain a significant challenge. Despite their importance, the mechanisms allowing HIV-1 entry and replication in the central nervous system (CNS) are poorly understood. Here, we show that α-synuclein and (to a lesser extent) Aβ fibrils associated with neurological diseases enhance HIV-1 entry and replication in human T cells,...

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PMID: 39827271
DOI: 10.1038/s41467-025-56099-z

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