Article

Discovering disease genetic variation impacting gene expression in 103 brain tissues with the Brain Ontology Expression (BRONTE) graph neural network model

2025-05-14

Abstract excerpt

Uncovering genes dysregulated in neuropsychiatric diseases promises to put forward therapeutic targets. By linking disease risk variants to tissue-specific gene regulation, the Genotype-Tissue Expression (GTEx) project has enabled discovery of disease genes and the brain tissues where these pathogenic effects occur. But, GTEx requires huge investment in obtaining human brain tissues, limiting the sample size and t...

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Literature Corpus work: 6ee7f9f4-7ac8-59bd-b083-fcafbc1b8b01
DOI: 10.1101/2025.05.08.652857

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