Article

Multiple stages of evolutionary change in anthrax toxin receptor expression in humans

2020-07-30

Abstract excerpt

The advent of animal husbandry and hunting increased human exposure to zoonotic pathogens. To understand how a zoonotic disease influenced human evolution, we studied changes in human expression of anthrax toxin receptor 2 ( ANTXR2 ), which encodes a cell surface protein necessary for Bacillus anthracis virulence toxins to cause anthrax disease. In immune cells, ANTXR2 was 8-fold down-regulated in all available...

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Literature Corpus work: 6e7efc20-3829-5d13-87bd-fa8ec64095b2
DOI: 10.1101/2020.07.29.227660

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