Article

A Computational and Statistical Framework Leveraging AI-Derived CT Phenotypes for Causal Mediation Effects Between Genetic Variants and Disease

2026-08-10

Abstract excerpt

As the costs of genetic sequencing continue to drop and human genomic biobanks grow in scale, the challenge in genomics has shifted increasingly towards disentangling whether and how associated genetic variants cause disease. Clinical imaging in health-system-based biobanks provides quantitative physiological measures that may help bridge this gap. Using genomic data linked to computed tomography (CT) scans from t...

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Literature Corpus work: 6e3d48d1-b2dd-5ed3-8c2e-df43baf8b812
DOI: 10.64898/2026.08.05.26359812

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