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Molecular and cellular heterogeneity of gastric cancer explained by methylation-driven key regulators

2020-01-28

Abstract excerpt

Gastric cancer (GC) is a heterogeneous disease of diverse genetic, genomic, and epigenetic alterations. Tumor microenvironment (TME) also contributes to the heterogeneity of GC. To investigate GC heterogeneity, we developed an Integrative Sequential Causality Test (ISCT) to identify key regulators of GC by integrating DNA methylation, copy number variation, and transcriptomic data. Applying ISCT to three GC cohort...

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Literature Corpus work
6e2fa820-2381-5e21-8fd9-8ad871cccd70
DOI
10.1101/2020.01.27.920744
Open publication

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Molecular and cellular heterogeneity of gastric cancer explained by methylation-driven key regulatorsDOI 10.1101/2020.01.27.920744
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