Article

MDR1 promotes CD8 T cell persistence in tumors and protects against cytotoxic chemotherapy

2025-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Multidrug transporters, including multidrug resistance-1 (MDR1), are recognized chiefly for effluxing chemotherapeutic drugs out of tumor cells. However, they are also expressed in many normal cells and tissues, including lymphocytes, but their physiological role is less well-understood. Here, we investigated the role of MDR1 in tumor-specific CD8 T cells (TST), which are critical in antitumor i...

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Literature Corpus work: 6e282126-6bb5-55b6-8c06-89ae8e03e4c7
DOI: 10.1101/2025.09.28.679049

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