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Strategies for overcoming ABC transporter-mediated multidrug resistance in colorectal cancer

16 Jul 2025

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with multidrug resistance (MDR) significantly limiting the effectiveness of chemotherapy. A major contributor to MDR is the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein ( ABCB1/P-gp), breast cancer resistance protein ( ABCG2/BCRP), and multidrug resistance-associated proteins ( ABCC/MRPs). These...

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PMID: 40668619
DOI: 10.1152/ajpcell.00412.2025

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