Article
A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.
PloS one - 1 Jan 2011
García-Arriaza Juan, Nájera José Luis, Gómez Carmen E, Tewabe Nolawit, Sorzano Carlos Oscar S, Calandra Thierry, Roger Thierry, Esteban Mariano
Abstract excerpt
The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown. Here, we have characterized the C6 protein and its effects in virus replication, innate immune sensing and immunogenicity in vivo. C6 is a 18.2 kDa protein, which is expressed early during virus infection and localizes to the cytoplasm of...
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