Article
Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-C.
PloS one - 1 Jan 2013
Perdiguero Beatriz, Gómez Carmen Elena, Di Pilato Mauro, Sorzano Carlos Oscar S, Delaloye Julie, Roger Thierry, Calandra Thierry, Pantaleo Giuseppe, Esteban Mariano
Abstract excerpt
Viruses have developed strategies to counteract signalling through Toll-like receptors (TLRs) that are involved in the detection of viruses and induction of proinflammatory cytokines and IFNs. Vaccinia virus (VACV) encodes A46 protein which disrupts TLR signalling by interfering with TLR: adaptor interactions. Since the innate immune response to viruses is critical to induce protective immunity, we studied...
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