Article

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

2024-02-20

Abstract excerpt

Succinate dehydrogenase inhibitors (SDHIs) are a promising class of fungicides targeting the energy production pathway of pathogenic fungi. However, overuse has led to resistance, necessitating the development of new and effective SDHIs. This study takes the Transformer model to generate a customized virtual library of potential SDHIs. These candidates were then meticulously screened based on expert knowledge and...

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Literature Corpus work: 6e11cbfb-9e4a-5271-8ea8-603e21008039
DOI: 10.1101/2024.02.20.581130

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